The Cancer is Spreading–STOP the Morphine

You have pain and cancer; your doctor reaches for his script pad and orders: 7,8-didehydro-4,5-epoxy-17-methyl-(5α, 6α)-morphinan-3,6-diol. Morphine. A widely and commonly used opiate, it is in fact the earliest of painkillers, isolated in 1803 by Sertürner. It is today still the most commonly used pain killer. But besides trying to alleviate your pain what is it doing to your cancer?

Scientist have known for years morphine increases the rate of tumor growth and the rate of migration of cancer cells causing an increased amount of metastases. Ever notice when cancer patients begin morphine they seem to get worse? And the morphine is increased due to the increase of cancer pain; more cancer, more pain until the vicious cycle ends in a funeral.

So what is occurring?

Mice with induced cancer given morphine showed it enhanced, rather than diminish, spontaneous pain, the studies indicated sustained morphine increases the pain, bone loss and spontaneous fractures. Studies show morphine in a concentration typically administrated in patients stimulates human microvascular endothelial cell proliferation and angiogenesis both in vitro and in vivo. The research results indicate clinical use of morphine promotes tumor neovascularization in human breast tumors, leading to increased tumor progression. It is also shown to stimulate the growth of glioblastoma tumors

A study done with rats showed carcinosarcoma cells produced subplueral pulmonary metastases when they were given morphine, the number of metastases increased. If given Naloxone they discovered the metastases proliferation could be decreased. Unless in a controlled study humans are not given the luxury of naloxone; therefore standard dosage is given regularly and the increase of metastases is an everyday occurrence as we much as we can assume.

In further studies they noted mice given morphine showed marked atrophy and a reduced amount of cellularity of the spleen and thymus demonstrating the immune system is greatly affected using morphine. The studies researched all noted data collected suggests morphine enhances tumor growth and results in an overall immunosuppressive effect.

Most scientist studying the use of morphine in cancer patients conclude, morphine can promote tumor growth and reduce the survival rate of cancer patients due to immunosuppression. Furthermore, cancer cells by majority have the ability to migrate, called metastases, they settle in surrounding or distant sites; most cancer deaths occur not from the primary cancer site but the main cause of ‘failure’ in cancer treatments is due to the metastases. In a study done by Shapiro in 1996 showed that uPA levels regulated by cancers were affected when morphine was administrated. The uPA levels in vitro demonstrated morphine caused marked increase of the secretion uPA in breast cells.

There is enough research documents and studies that show doctors should cautiously use morphine in patients with cancer. If the goal is to put patients into remission, there is strong evidence to show morphine will inhibit that process. Tumor growth and increased metastases go hand in hand with morphine,

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A scan shows metastases in the hip and spine; the doctor prescribes morphine to one woman; her pain increases over some weeks and the morphine is increased. Desperate and afraid to die she sought treatment in a remote clinic. There a new scan was done, just weeks after her scan revealed some bone mets. The astonishing new scan revealed her cancer had spread significantly to nearly 80 percent of her body. The only medication given was morphine. The woman so shocked, stopped the morphine, underwent her new treatment and reported that her pain had decreased by nearly 90 percent.

Pain during treatment of cancer where the patient is not considered in a death watch should not be given morphine or the direct result could be lack of survival.

Do you have cancer? Are you looking for information and support? Find sources and support at www.jesichashope.org or contact us: info@jesichashope.org Discover us on facebook: www.facebook.com/jeschashope or join in open discussions: www.facebook.com/groups/alternativecancertreatments Afraid to discuss your cancer publicly or your view, join our private forum found at: www.ourcancerspot.com

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Resources:

http://www.sciencedirect.com/science/article/pii/S0304395907003508

http://cancerres.aacrjournals.org/content/62/15/4491.short

http://www.sciencedirect.com/science/article/pii/0361923086900572

https://www.jstage.jst.go.jp/article/bpb1993/16/8/16_8_762/_article

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158334

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35 comments on “The Cancer is Spreading–STOP the Morphine

  1. John Carpenter

    I had a gallon or so in ICU, am getting off of hydrocodone. Was on 12 a day after lung removes. Whats the best way to ween off?I can’t seem to go lower than 1 and a half a day

  2. Grace Bell

    That treatment is surely out of the dark ages of cancer treatment. Ove the last nine days I’ve tuned into the docu-series ‘The only anser to Cancer’ The quest for the cures, the final episode #9, the most awesome testimonies, it has got to be seen by the whole world, especially those that conventional medicine is not helping. Cancer doe snot have to be a death sentence, belive it, it is true. Good luck in your quest.

    1. Nancy Luckhurst

      Look up Michael McShane. He cured skin cancer on his face and yes it did cure. Also check out Lynnice Wedewer. She has used it for several bouts of cancer over decades and is also using it right now.

    1. jesichashope

      Try to ask for Tramadol we have a good source that tells us it works. Many clients of Jesicha’s Hope have used it. There are no known problems with tumor growth

      1. Colin Millbank

        I have been on an increasing dose of tramadol for 3+ years, for neck and back pain. It’s worked very well, but I’ve reached maximum dose of 400mg per day. I’m being taken off tramadol and have been prescribed Norspan, a morphine patch of 5mg. I’m a 55 year old just wanting relief from constant pain ! I’m a bit concerned now that it could be doing Me more damage than good??? Whats Your opinion of apricot kernels as a treatment ??

      2. Janet Golden

        I was pretty glad to hear you recommend Tramadol because I take that and I am in chemo. I always suspected it because it’s a manmade kinda thing, but I like it. A therapist told me people take it for anxiety, but really paid, in her biz, although it’s ‘off-purpose’ or whatever that term is… It gives me great energy, and I just feel good. I take 3 or so a day. Thanks! If you can point me to any more info I would appreciate it. I like it also because one doesn’t have to go through all that rigamarole to get it.

      1. jesichashope

        Yes cannabis oil is good for pain and has been used for centuries for pain. This is one of the best uses for cannabis. We are not so convinced it is a cure; it can kill but not seeing those miraculous cures as everyone talks about. Lots of pain going away and appetite occurring, not so much the miracle cure. Indeed, cannabis for pain.

  3. Helen Latta

    What treatment in what remote clinic? This article is not very forthcoming with the alternative treatment that is so miraculous but apparently can’t be revealed.

    1. jesichashope

      Helen, if you want to know more in that regard kindly get hold of a staff member at Jesicha’s Hope – info@jesichashope.org. They will help you with the information you want.
      The article was to focus on the topic of morphine and what it can do to cancer growth therefore taking the focus off that topic to discuss how she is being treatment would not have fair to the topic.

  4. Skptical Root

    We actually don’t know that this is true. You link to one article and four abstracts as sources. Three of the abstracts are very specific to certain opioids and certain cancers in mice, not humans. The one link about humans (bone cancer) doesn’t show increased cancer growth, but can lead to bone loss and increased pain for the patient (according to the abstract). But because they are behind a paywall (in some cases) I can’t see any relevant info, such as sample size, duration, methodologies, that might help evaluate the efficacy of the studies. The article is refuted by the link here – http://www.geripal.org/2009/11/does-morphine-stimulate-cancer-growth.html Your last link is malformed so it doesn’t go anywhere.

    1. jesichashope

      Skeptic, the link you noted was fixed, an upload glitch.

      The article you supplied was written by someone that did not do their homework; had they looked into scientific reports they would have noted the many studies that have been done over the past near two decades to indicate morphine at a normal dosage given to most cancer patient is sufficient to increase tumor growth and increase metastases.
      You mentioned that most of the studies were done with mice. It would be hardly human if there was a double blind study done to see if giving morphine to one group would make their cancer increase to a point where they would not survive; the other group given some other form of medication to see how they fared. Would you want to be in the trial? In these case studies it ethical to use mice or rats.
      As you may see in the scan report we included, this particular patient had a scan done shortly prior to the scan included; the only change was adding morphine to her regiment. There was a dramatic increase in cancer metastases during that time period.
      If there is another method of killing pain in a patient that still has hope to survive why not use it? If you are a skeptic, would it not be wise to err on the side of caution rather than to take a risk?

      1. Daz Gally

        i notice skeptic didnt comeback jessica ,well done on putting him straight ,my first thought would have been how many people do i know who have been put on morphine in hospital made it out of hospital ,that would be none

      2. Michelle

        Could it be possible that this particular patient had a progressing cancer and therefore the scans showed disease progression? I’ve read the supporting articles and this article is jumping to some pretty hefty conclusions.

      3. jesichashope

        The patient that was used in the article had the progression over a short time – before this, her cancer progressed a rate that would be considered typical for her lung cancer; the progression after going on morphine was 10 fold; it grew rapidly. Before her scan showed about three small spots on her spine and a couple on her ribs. After a short time she complained of more pain and another scan showed more rapid growth, she increased the morphine and shortly thereafter the couple looked for treatment outside the conventional arena. Her scan as shown was taken once she arrived in Asia. Even the conventional doctors agreed her metastases was excessively aggressive and her dose of morphine was near a lethal dosage.
        She has since had further scans and her cancer is now nearly undetectable. She is still undergoing treatment for her complaints.

    2. jesichashope

      If people want to be skeptical they need to do more due diligence. There are a dozen more studies we did not use, all reiterating the same conclusion. While a patient in their last days deserved to use morphine to give them some peace, if they are in pain. But to use it while treating cancer in hopes of survival for the patient is not justified, like putting on the gas and brakes on you car at the same time – not going to work.

      1. Sam

        I’m not being cheeky here, just wonder ….if a person is reaching their demise, why would they want something to increase their pain?

    1. jesichashope

      Jeff, not such a silly question. Based on the fact our sources were from medical scientific reports, we would hope doctors would read; fact is most doctors say they don’t have the time to read most studies therefore, therein is your answer. The research end of the medical industry knows it; the other end of the medical industry has a deaf ear to it because they are too busy, the information that is critical never reaches the decision makers. You suffer the consequences.

  5. violetlorien

    I rarely comment anywhere, but cherry picking data to talk cancer patients out of receiving what is in many cases essential pain management treatment is something that really bothers me. It took me about 30 seconds to find this detailed, well sourced article discussing just how complex this issue is: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158334/

    In particular, they discuss how depending on multiple factors which are not fully understood, morphine and other opiates can *inhibit* tumor growth as well as trigger apoptosis. For example, “…tumor suppression occurs after chronic high doses of morphine, while tumor-enhancing effects with morphine occur after a single dose or low daily doses (Zong and Pollack 2000). This dual concentration-dependent effect, i.e., mitogenesis at low and growth inhibition at higher concentrations was observed both in vitro and in vivo.” Whether morphine or another opiate causes tumor growth or inhibits it appears to vary greatly between different types of cancer, dosages and concentrations, and other factors:
    “However, significant differences between cell lines were found. For example, morphine produced a higher number of necrotic cells in the MCF-7 breast cancer cell line than in the A549 lung cancer cell line (Hatsukari et al. 2007).”

    There is a lot more information packed into this article, along with plenty of references, but the conclusion is clear – there is no final answer:
    “However, the results obtained both in in vitro and in vivo studies are conflicting. On one hand, morphine was shown to induce tumor growth, inhibit apoptosis, promote angiogenesis and migration of tumor cells, but on the other hand, pro-apoptotic and anti-angiogenic properties of morphine were also demonstrated. Performed studies were very heterogenic due to the different doses of morphine applied, and the effects may vary when the experiments were performed in vivo or on isolated cells. The dose and route of administration of morphine might be critical factors that need to be taken into consideration in clinical settings. Contradictory results that have been obtained induce further studies. The final answer to the question whether morphine is an inhibitor of tumor growth or whether it promotes cancer is still to be sought.”

    This is clearly a complex question, and whether to receive morphine for cancer pain should always be a personal, careful, informed choice between each patient and their doctor. That there is a wide variance in the research is a critical fact you left out of your article. (Not to mention that multiple studies show tumor inhibition, not growth.) As cancer patients we can’t make informed decisions with only half the facts.

      1. jesichashope

        Yes it is a complex issue and the decision to use morphine or a morphine based pain medication is not to be taken lightly. If there are other things that can be used to alleviate the pain that might be considered should your cancer case be in a stage where further treatment could give you remission. A well advanced cancer sufferer might consider using morphine if there has been an acceptance there is nothing more to be done and heavy amounts of chemo and radiation has given painful side effects as well. No two cases are alike and no two decisions are the same.

  6. vicky

    Hi I just come across this article and so wish id seen this a couple of months ago my friends son aged 10 recently past away from a glioblastoma tumor they didn’t find it till Christmas last year he has chemotherapy which shrunk it but then came back more aggressively and went down hill quickly and sadly past 2 weeks ago and feel so sad for his mum and now she is blaming herself saying if only she had noticed something was wrong sooner and fighter the doctors more when they said there was nothing wrong with him then nothing more they could do my heart breaks for her as she did everything for him made his last mnths memorable its heart breaking that they are aware of these tests yet don’t inform parents patients to make there own mind up rather then pushing what they want on them and not giving them a choice

  7. Andy Singletary

    A person’s Ph levels are important. I have heard some pretty wild success stories from cancer patients using a combination of cannabis and this new/ancient substance called Ormus, and Mono-atomic minerals broken down to a level that is readily usable by the body’s digestive system.

    1. cindy monaco

      I too have heard that ph levels are important. I heard of a Dr. in Italy who uses baking soda as part of treatment. 1 tbsp baking soda mix w/a half cup of warm water then sweeten it up w/ honey or a strong sweetener. ( cancer cells consume 15 times the sugar than any other cells in your body ) drink this twice a day for 30 days then 1 time a day after that. (check YouTube – baking soda and cancer. A friend of mine did it and saw a reduction in the size of his tumor!!! Incredible!!!!!

    2. jesichashope

      pH is very important however just balancing pH will not cure the disease. Studies not a reduction in tumor growth or tumor size; rarely is there mention of tumor elimination or disease elimination, this is what people want. People want to live, we need full longterm remissions.

  8. N

    Have you come across any credible sources not found online?

    1. jesichashope

      We have had numerous doctors and nurses come to us with this same information. This is peer reviews of their experience and in the world of science since it is not controlled it is often discounted; however if one is considering this medication it is good to know there are peer experiences as well as research that shows it might not be the wisest choice if the treatment you are undergoing may bring you into remission, Another medication might be far more helpful. It is always, I repeat, always the choice of the patient to make the ultimate decision.

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  10. Damon

    My only question is why oh why do we have opiate receptor cells in our brain, almost as if to trick us into its validity? I’m confused, Damon.

  11. getruida

    I am shocked about the morphine my daughter drink a lot when she was on chemo.

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